Intra Cytoplasmic Sperm Injection-(ICSI)
What is ICSI and why is it necessary?
Prasad Infertility Solutions is the Best ICSI treatment Hospital in Hyderabad. Intracytoplasmic Sperm Injection (ICSI) refers to the technique of injecting a single sperm into the center (cytoplasm) of the egg. In natural conception, a large number of sperms surround the egg and many attach to the outside, but only one sperm penetrates and fertilizes each egg. In standard IVF, we mimic nature by adding a large number of sperms to the dish containing the egg. In the ICSI procedure, the embryologist selects sperm concerning their activity and appearance. A single sperm is then injected into each mature egg using specialized equipment, the microinjection system that allows the egg and sperm to be handled precisely.
Which couples require ICSI?
ICSI is recommended in cases where there is a clear sperm problem, as otherwise there is a risk that the eggs may fail to fertilize.
- •If a sperm problem is known beforehand, the team at Prasad Infertility solutions who are the Best Fertility Specialists in Hyderabad will advise that you undergo ICSI.
- •You are using surgically retrieved sperm, ICSI is the best suitable technique due to fewer available spermatozoa.
If the tests found that there is no sperm problem, it is advised to have standard IVF, as ICSI is not needed for those couples. Sometimes on the day of egg collection, sperm quality may be poor. If this happens, we will carry out ICSI to try to achieve fertilization.
We may also recommend ICSI if you have had standard IVF and there was a very low fertilization rate or no fertilization. If this happens in your case, Dr. Suma Prasad, the Best Fertility Specialist in Hyderabad, will discuss the alternatives apart from ICSI.
How is ICSI carried out?
Except for the method of fertilization, every other aspect of your treatment cycle is identical for ICSI and conventional IVF, including hormonal stimulation, egg recovery, producing the sperm sample and embryo replacement in the woman’s womb.
During ICSI, our embryologist removes the cumulus cells using an enzyme that is produced by sperm. Then, the embryologist with the help of a microscope tests the egg whether it is matured or not. Only the matured eggs can be used in this process. Mostly 80% of eggs are matured in all treatment cycles.
The embryologist then picks out individual live sperm, of normal appearance and injects one into each egg, using a special glass needle. After ICSI the eggs are returned to the incubator overnight and checked for fertilization the following morning, as for conventional IVF.
How successful is ICSI?
Approximately 6 out of every 10 eggs will fertilize successfully by ICSI, similar to IVF. The reasons for ICSI fertilization not being 100% successful include:
- • Immature eggs cannot be injected.
- • By the procedure of injection, some eggs may be damaged which are related to the properties of the inner egg membrane.
- • Many Sperms may not be capable of activating the egg when injected directly into the egg.
Following successful fertilization, embryo development is similar for ICSI and IVF. Following embryo transfer, pregnancy rates are similar to IVF.
What risks are associated with ICSI treatment?
ICSI can give the opportunity of success for the many couples, on the other hand, ICSI carries many risks. It is known that abnormal sperm production, as is the case in men with very low sperm count or absent sperm in the ejaculate, can be associated with genetic defects in the male. As ICSI bypasses the normal processes of sperm ‘selection’ and fertilization, these genetic defects may be transmitted to the children. The egg may also get damaged by the injection procedure. Theoretically, this can result in damage to the resulting embryo if the damaged egg is fertilized normally.
Fortunately, evidence supported by recent studies reported no difference in the risk for any anomaly or specific anomalies after different types of IVF technologies including ICSI. It should be borne in mind that the great majority of babies born by ICSI do not display any abnormalities.
Counseling session by our team of doctors before the procedure selection is a regular practice at Prasad Infertility Solutions, the Best Infertility Hospital in Hyderabad and has strengthened the bond between the couple and our experts to face both success and failures associated with the assisted reproductive technologies.